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methylprednisolone will lessen the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.diazepam will increase the level or influence of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. If coadministration of lonafarnib (a sensitive CYP3A